Table of Content

This page summarizes the available resources. Articles, interviews, videos. It will be updated constantly to allow direct access to everything that is published.


Instructions for the use of high doses of thiamine (thiamine hydrochloride) in Parkinson’s disease.

Frequent questions


In this section you can find publications that discuss the use of high doses of thyamin. The articles report real cases treated by doctor Costantini.

Articles should not be downloaded and used for any purpose without the written agreement of the editor.

High-dose thiamine improves the symptoms of fibromyalgia

High-dose thiamine and essential tremor

Thiamine and spinocerebellar ataxia type 2

Thiamine and Fatigue in Inflammatory Bowel Diseases: An Open-label Pilot Study

Thiamine and Hashimoto’s Thyroiditis: A Report of Three Cases

High-Dose Thiamine Improves Fatigue After Stroke: A Report of Three Cases

High-dose thiamine as initial treatment for Parkinson ’ s disease

An open-label pilot study with high-dose thiamine in Parkinson’s disease

High dose thiamine improves fatigue in multiple sclerosis

Long-term treatment with thiamine as possible medical therapy for Friedreich ataxia

High-dose thiamine improves the symptoms of Friedreich’s ataxia

Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache

Thiamine Therapy for Dystonia Type 1

Long-Term Treatment with High-Dose Thiamine in Parkinson Disease: An Open-Label Pilot Study

YouTube Channel

Dr. Costantini and his collaborators have opened a YouTube channel. The channel contains videos of patients (who have provided written consent to the publishing of the video material) before and after the high dose thiamine therapy in different diseases.

Other Websites and Articles  Website curated by Dr. costantini’s team that discusses the use of high doses of thiamine to treat a number of neurodegenerative diseases.